With more than 20 flights a day from across Turkey, it is very convenient to arrive in Adana by plane the Adana Sakirpasa Airport (IATA: ADA)  is located in the city outskirts. It's a fairly short cab ride to city center and is served frequently by dolmus (local buses).

   
The best route from Istanbul or Ankara is to take the YHT fast train to Konya, whence there is a replacement bus service to Karaman, then 4½ hours by daily train to Adana. The line between Konya and Karaman is closed for upgrading to YHT until 2018.

 

 
As with the rest of the country, another common way of getting here is to use the buses. They arrive here frequently from Ankara, Istanbul, Izmir, and several other cities around Turkey. Journey time from Istanbul is around twelve hours, fares starting around 12 US Dollars.

 Make sure you get off at the right station as most buses also stop at a station in the suburbs, about 4 km west of city centre. Getting off at the wrong station may be frustrating, but not an disaster since a local bus connects them. The bus station in city centre lies close to the Hilton hotel.

Courtesy of https://wikitravel.org/en/Adana